Antiviral Activity of Propyl Gallate against Replication of Dengue Virus Serotype 2: In Vitro and In Silico Study

Introduction: Dengue fever (DF) and dengue hemorrhagic (DHF) are infectious diseases caused by virus (DENV) with high mortality rates. The mainstay of treatment for DENV infection is supportive, since there were no commercial specific antiviral drug DENV. Propyl gallate has potential to be an antivirus However, the mechanism still unknown. This study aims identify activity propyl in DENV-2 replication vitro analyze binding energy towards NS3 NS5 protein silico.
 Methods: We used serotype 2 New Guinea C Vero cells study. Focus MTT assay was conducted measure inhibition percentage viability percentage. Furthermore, silico constant dan protein.
 Results: pre post 4,34±7,53% 30,7±4,88% 94,64±0,4% 95,31±3,38%, respectively. NS5, protease, helicase -3,49 kcal/mol, -2,47 -3,72 kcal/mol.
 Conclusion: adhesion-replication low